Resolution of ROS

Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of potentially damaging levels of reactive oxygen species (ROS), Ca(2+), etc., which must be normalized. Evidence suggests that brief mitochondrial permeability transition pore (mPTP) openings play an important physiological role maintaining healthy mitochondria homeostasis. Adaptive and maladaptive responses to r...

Ros

Do you have any strong views on journals and the peer review system? The peer review system isn’t perfect, but I think it will continue to be better than the alternatives as long as we have hardworking and judicious editors. It worries me that an increasing number of action letters appear to have been written by someone who hasn’t read the article, and just took a head count of reviewers in fav...

Reactive Oxygen Species (Ros-Induced) Ros Release

We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of increased ROS production at sites of spontaneously deenergized mitochondria. We devised a new model enabling incremental ROS accumulation in individual mitochondria in isolated cardiac myocytes via photoactivation of t...

Fluorescent Nitrones for the Study of ROS Formation with Subcellular Resolution

P-19: Association of Poor Chromatin Remodeling with Cytosolic ROS and Mitochondrial ROS in Sperm of Infertile Men

Background: Cytoplasm and mitochondria are considered as the major origins of sperm ROS production. Sperm is prone to DNA damage by exposure to ROS or due impaired chromatin remodeling or low DNA protamination. Therefore, the aim of this study was to see if there is any association between impaired chromatin packaging and origin of ROS production. Materials and Methods: Cytosolic ROS, mitochond...